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Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1967 2
1968 1
1969 1
1970 2
1972 1
1973 1
1975 1
1976 3
1977 4
1980 2
1981 1
1982 1
1983 2
1984 1
1985 2
1986 7
1987 2
1988 2
1989 2
1990 5
1991 2
1992 1
1993 2
1996 3
1997 4
1998 3
1999 3
2000 1
2001 3
2002 4
2003 2
2004 3
2005 3
2006 3
2007 1
2008 5
2009 2
2010 3
2011 3
2012 5
2013 4
2014 4
2015 7
2016 7
2017 8
2018 9
2019 6
2020 7
2021 8
2022 8
2023 5
2024 2

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160 results

Results by year

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Page 1
Combination pharmacotherapy for the treatment of fibromyalgia in adults.
Thorpe J, Shum B, Moore RA, Wiffen PJ, Gilron I. Thorpe J, et al. Cochrane Database Syst Rev. 2018 Feb 19;2(2):CD010585. doi: 10.1002/14651858.CD010585.pub2. Cochrane Database Syst Rev. 2018. PMID: 29457627 Free PMC article. Review.
Three studies combined a non-steroidal anti-inflammatory drug (NSAID) with a benzodiazepine (306 participants); two combined amitriptyline with fluoxetine (89 participants); two combined amitriptyline with a different agent (92 participants); two combined melatonin with an antide …
Three studies combined a non-steroidal anti-inflammatory drug (NSAID) with a benzodiazepine (306 participants); two combined amitriptyline w …
Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box.
Mercaldi GF, Eufrásio AG, Ranzani AT, do Nascimento Faria J, Mota SGR, Fagundes M, Bruder M, Cordeiro AT. Mercaldi GF, et al. ACS Infect Dis. 2021 Aug 13;7(8):2455-2471. doi: 10.1021/acsinfecdis.1c00231. Epub 2021 Jul 19. ACS Infect Dis. 2021. PMID: 34279922
In the present work, we report the screening of the Chagas Box against T. cruzi malic enzymes (MEs) and the identification of three potent inhibitors of its cytosolic isoform (TcMEc). ...
In the present work, we report the screening of the Chagas Box against T. cruzi malic enzymes (MEs) and the identification of three p …
Effects of fructans-type prebiotics on lipid metabolism.
Delzenne NM, Kok N. Delzenne NM, et al. Am J Clin Nutr. 2001 Feb;73(2 Suppl):456S-458S. doi: 10.1093/ajcn/73.2.456s. Am J Clin Nutr. 2001. PMID: 11157357 Review.
The triacylglycerol-lowering action of oligofructose is due to a reduction of de novo fatty acid synthesis in the liver through inhibition of all lipogenic enzymes, namely acetyl-CoA carboxylase (EC 6.4.1.2), fatty acid synthase, malic enzyme (EC 1.1.1.40), ATP citrate lya …
The triacylglycerol-lowering action of oligofructose is due to a reduction of de novo fatty acid synthesis in the liver through inhibition o …
Astrocytes: glutamate producers for neurons.
Hertz L, Dringen R, Schousboe A, Robinson SR. Hertz L, et al. J Neurosci Res. 1999 Aug 15;57(4):417-28. J Neurosci Res. 1999. PMID: 10440891 Review.
The most far-reaching innovations have been: i) to exclude the brain from access to glutamate in the systemic circulation by the blood-brain barrier, thereby making the brain autonomous in the production and disposal of glutamate; ii) to surround glutamatergic synapses with glial …
The most far-reaching innovations have been: i) to exclude the brain from access to glutamate in the systemic circulation by the blood-brain …
In the Quest for Potent and Selective Malic Enzyme 3 Inhibitors for the Treatment of Pancreatic Ductal Adenocarcinoma.
Sheth G, Shah SR, Sengupta P, Jarag T, Chimanwala S, Sairam KVVM, Jain V, Talwar R, Dhanave A, Raviya M, Menon S, Trivedi S, Chitturi TR. Sheth G, et al. ACS Med Chem Lett. 2022 Dec 13;14(1):41-50. doi: 10.1021/acsmedchemlett.2c00369. eCollection 2023 Jan 12. ACS Med Chem Lett. 2022. PMID: 36655126 Free PMC article.
The genome of pancreatic ductal adenocarcinoma (PDAC) is associated with frequent deletion of the tumor suppressor gene SMAD family member 4 (SMAD4) with collateral deletion of its chromosomal neighbor malic enzyme 2 (ME2). In SMAD4 (-/-) /ME2 (-/-) PDAC cells, ME3 takes o …
The genome of pancreatic ductal adenocarcinoma (PDAC) is associated with frequent deletion of the tumor suppressor gene SMAD family member 4 …
Sulfinamide Formation from the Reaction of Bacillithiol and Nitroxyl.
Negrellos A, Rice AM, Dos Santos PC, King SB. Negrellos A, et al. ACS Chem Biol. 2023 Dec 15;18(12):2524-2534. doi: 10.1021/acschembio.3c00526. Epub 2023 Nov 27. ACS Chem Biol. 2023. PMID: 38012810
Treatment of a glucosamine-cysteine conjugate, which lacks the malic acid group, with HNO forms disulfide, implicating the malic acid group in sulfinamide formation. This finding supports a mechanism involving the formation of an N-hydroxysulfenamide intermediate th …
Treatment of a glucosamine-cysteine conjugate, which lacks the malic acid group, with HNO forms disulfide, implicating the malic
Malic enzyme and glucose 6-phosphate dehydrogenase gene expression increases in rat liver cirrhogenesis.
Sanz N, Díez-Fernández C, Valverde AM, Lorenzo M, Benito M, Cascales M. Sanz N, et al. Br J Cancer. 1997;75(4):487-92. doi: 10.1038/bjc.1997.85. Br J Cancer. 1997. PMID: 9052398 Free PMC article.
The cirrhogenic ability of thioacetamide has been used to induce a model of chronic generalized liver disease that resembles the preneoplastic state of human fibrosis. Malic enzyme (ME) and glucose-6-phosphate dehydrogenase (G6PDH) are two cytosolic NADPH-generating enzyme …
The cirrhogenic ability of thioacetamide has been used to induce a model of chronic generalized liver disease that resembles the preneoplast …
Natural deep eutectic solvents combined with cyclodextrins: A novel strategy for chokeberry anthocyanins extraction.
Jovanović MS, Krgović N, Radan M, Ćujić-Nikolić N, Mudrić J, Lazarević Z, Šavikin K. Jovanović MS, et al. Food Chem. 2023 Mar 30;405(Pt A):134816. doi: 10.1016/j.foodchem.2022.134816. Epub 2022 Nov 3. Food Chem. 2023. PMID: 36345100
Nine different NaDES composed of choline chloride as a hydrogen bond acceptor and organic acids (lactic, citric, malic), sugars (glucose, fructose), polyols (glycerol, 1,2-propanediol, sorbitol), and an amide (urea) as hydrogen bond donors were screened. Malic
Nine different NaDES composed of choline chloride as a hydrogen bond acceptor and organic acids (lactic, citric, malic), sugars (gluc …
160 results